The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance. These are but a few highlights of how the terrain has changed in a relatively brief period of time. In keeping with these advances, the title of this book has been revised to reflect the growing importance of PCOS as the most prevalent androgen excess disorder in women, and arguably, as the one that might have the most serious adverse consequences for general health. There are fewer chapters to provide a more focused elucidation of the area. Several chapters were penned by new (and young) authors who are conducting cutting-edge research in the field.

InhaltsangabeI. Introduction A Brief History of Androgen Excess Ricardo Azziz II. Physiology of Androgens Ovarian and Adrenal Androgen Biosynthesis and Metabolis Walter L. Miller, David H. Geller, and Mitchell Rosen Androgens Throughout the Life of Women C. Richard Parker, Jr. Physiologic Effects of Androgens in Women T. Keta Hodgson and Glenn D. Braunstein Androgen Measurements: Methods, Interpretation and Limitations Frank Z. Stanczyk III. Pathophysiology of Androgen Excess AndrogenSecreting Adrenal and Ovarian Neoplasms Michel Pugeat, Gérald Raverot, Ingrid Plotton, Aude Brac de la Perrière, Pascale Mirakian, Henri Déchaud, Nicole Berger, and Jean Louis Peix Cushing's Syndrome Acromegaly and Androgen Excess AnneCéline REYSS, Didier Dewailly The Non Classic Adrenal Hyperplasias Didier Dewailly and Ricardo Azzizb PregnancyRelated Androgen Excess Howard D. McClamrock DrugInduced Hyperandrogenism Christine Cortet-Rudelli and Didier Dewailly The Severe Insulin Resistant Hyperandrogenic Syndromes David E. Moller, Antonio Vidal-Puig, and Ricardo Azziz Idiopathic Hirsutism Enrico Carmina Definition and Epidemiology of the Polycystic Ovary Syndrome Ricardo Azziz Clinical Features of PCOS W. Futterweit, E. Diamanti-Kandarakis, and Ricardo Azziz Biochemical Features of the Polycystic Ovary Syndrome Adam Balen Ovarian Histology, Morphology and Ultrasonography in PCOS Sophie Jonard, Yann Robert, Yves Ardaens, and Didier Dewailly HypothalamicPituitaryGonadotropic Dysfunction in PCOS R. Jeffrey Chang and Rinku V. Mehta Ovarian Steroidogenic Abnormalities in PCOS Denis A. Magoffin HypothalamicPituitary Adrenal Dysfunction in Polycystic Ovary Syndrome Bulent O.Yildiz, Enrico Carmina, and Ricardo Azziz The Genetic Basis of Polycystic Ovary Syndrome Mark O. Goodarzi Pediatric Hyperandrogenism Kathleen M. Hoeger Environmental Factors in the Polycystic Ovary Syndrome MarieFrance Hivert and JeanPatrice Baillargeon Animal Models and Fetal Programming of PCOS David H. Abbott, Daniel A. Dumesic, Jon E. Levine, Andrea Dunaif, and Vasantha Padmanabhan Insulin Resistance and Hyperinsulinism in PCOS Paulina A. Essah and John E. Nestler The Endocrine Impact of Obesity and Body Habitus in PCOS Pasquali Renato and Gambineri Alessandra Molecular Mechanisms of Insulin Resistance in PCOS Theodore P. Ciaraldi Menstrual Dysfunction and Endometrial Neoplasia Abdulkadir Wagley and Paul Hardiman Beta Cell Dysfunction, Glucose Intolerance, and Diabetes in PCOS David A. Ehrmann Hypertension, and Cardiovascular and Lipoprotein Abnormalities Francesco Orio and Stefano Palomba Reproductive and Obstetrical Consequences of Polycystic Ovary Syndrome Mary C. Johnson and Richard S. Legro Psychosocial and Quality-of-Life Consequences of Androgen Excess Onno E. Janssen, Susanne Hahn, and Sigrid Elsenbruch Overview of Long-Term Morbidity and Economic Cost of PCOS Ricardo Azziz IV. Evaluation and Treatment of Androgen Excess Clinical and Hormonal Evaluation of Androgen Excess Ricardo Azziz Ovarian Suppression and Treatment of Hirsutism Paolo Moghetti Polycystic Ovary Syndrome and Ovulation Induction Bulent O. Yildiz and Ricardo Azziz In Vitro Fertilization for Polycystic Ovary Syndrome Hanadi BaAkdah, Ezgi Demirtas, Hananel Holzer, William Buckett, and Seang Lin Tan The Surgical Management of Polycystic Ovary Syndrome Adam Balen Use of Insulin Sensit

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The Latest Research Findings on Androgen Excess Disorders in Women