An exploration of the raw power of genetic material to refashion itself to any purpose
Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome.Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability.
Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that
covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsiblepresents a detailed account of the many different recombination systems that can rearrange genomesexamines the tremendous impact of mobile DNA in virtually all organisms
Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms.
Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.
I. Introduction
1. A Moveable Feast: An Introduction to Mobile DNA
II. Conservative Site-Specific Recombination
2. An Overview of Tyrosine Site-specific Recombination: From an Flp Perspective
3. The Serine Recombinases
4. The lambda Integrase Site-specific Recombination Pathway
5. Cre Recombinase
6. The Integron: Adaptation On Demand
7. Xer Site-Specific Recombination: Promoting Vertical and Horizontal Transmission of Genetic Information
8. The Integration and Excision of CTnDOT
9. Site-specific DNA Inversion by Serine Recombinases
10. Serine Resolvases
11. Phage-encoded Serine Integrases and Other Large Serine Recombinases
12. Hairpin Telomere Resolvases
13. Biology of Three ICE Families: SXT/R391, ICEBs1, and ICESt1/ICESt3
III. Programmed Rearrangements
14. V(D)J Recombination: Mechanism, Errors, and Fidelity
15. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
16. Programmed Genome Rearrangements in Tetrahymena
17. Programmed Rearrangement in Ciliates: Paramecium
18. Programmed Genome Rearrangements in the Ciliate Oxytricha
19. DNA Recombination Strategies During Antigenic Variation in the African Trypanosome
20. Recombination and Diversification of the Variant Antigen Encoding Genes in the Malaria Parasite Plasmodium falciparum
21. Mobile DNA in the Pathogenic Neisseria
22. vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity
23. Mating-type Gene Switching in Saccharomyces cerevisiae
24. A Unique DNA Recombination Mechanism of the Mating/Cell-type Switching of Fission Yeasts: a Review
IV. Dna-Only Transposons
25. Mechanisms of DNA Transposition
26. Everymans Guide to Bacterial Insertion Sequences
27. Copy-out-Paste-in Transposition of IS911: A Major Transposition Pathway
28. The IS200/IS605 Family and Peel and Paste Single-strand Transposition Mechanism
29. Transposons Tn10 and Tn5
30. Tn7
31. Transposable Phage Mu
32. The Tn3-family of Replicative Transposons
33. P Transposable Elements in Drosophila and other Eukaryotic Organisms
34. Mariner and the ITm Superfamily of Transposons
V. LTR Retrotransposons
35. hAT Transposable Elements
36. Mutator and MULE Transposons
37. Adeno-associated Virus as a Mammalian DNA Vector
38. Sleeping Beauty Transposition
39. piggyBac Transposon
40. Helitrons, the Eukaryotic Rolling-circle Transposable Elements
41. Ty1 LTR-retrotransposon of Budding Yeast, Saccharomyces cerevisiae
42. Ty3, a Position-specific Retrotransposon in Budding Yeast
43. The Long Terminal Repeat Retrotransposons Tf1 and Tf2 of Schizosaccharomyces pombe
44. Retroviral Integrase Structure and DNA Recombination Mechanism
45. Host Factors in Retroviral Integration and Selection of Integration Target Sites
46. Reverse Transcription of Retroviruses and LTR Retrotransposons
47. Mammalian Endogenous Retroviruses
48. Retroviral DNA Transposition: Themes and Variations
VI. Non-LTR Retrotransposons
49. Integration, Regulation, and Long-Term Stability of R2 Retrotransposons
50. Site-Specific non-LTR retrotransponsons
51. The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes
52. Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution
53. Diversity-generating Retroelements in Phage and Bacterial Genomes
54. An Unexplored Diversity of Reverse Transcriptases in Bacteria
55. Tyrosine Recombinase Retrotransposons and Transposons
Index
